Atlas of Genetics and Cytogenetics in Oncology and Haematology MIR 27 A ( microRNA 27 a )

MiR-27 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-27 precursor is the microRNA, miR-27. Herpesvirus saimiri expresses several noncoding RNAs (HSURs) which have been found to significantly reduce the level of miR27 in a host cell. It has been proposed that miR-27 operates together with miR-23 and miR-24 in a cooperative cluster. This miRNA was previously named miR-27 but is renamed here to avoid confusion with the more recently described miR-27b (MI0000440).